AN EVALUATION OF A SVA RETROTRANSPOSON IN THE FUS PROMOTER AS A TRANSCRIPTIONAL REGULATOR AND ITS ASSOCIATION TO ALS.

An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.

Genetic mutations of FUS have been linked to many diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration.A primate specific and polymorphic retrotransposon of the SINE-VNTR-Alu (SVA) family is present upstream of the FUS gene.Here we have demonstrated that this retrotransposon can act as a classical transcripti

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Adapting evidence-informed complex population health interventions for new contexts: a systematic review of guidance

Abstract Background Adapting interventions that have worked elsewhere can save resources associated with developing new interventions for each specific context.While a developing body of evidence shows benefits of adapted interventions compared with interventions transported without adaptation, there are also examples of interventions which have be

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